The 22nd Alabama Infantry Regiment was first organized at Montgomery on 6 October 1861, and was encamped at Mobile during that winter. Men were recruited from Calhoun, Cherokee, Choctaw, Clarke, Mobile, Montgomery, Pike, Randolph, and Walker counties. Ordered to west Tennessee, it was brigaded under Gen'l Adley Gladden of Louisiana. The regiment was engaged at Shiloh, with heavy loss (reported 123 men fit for duty after). Later, Gen'l Frank Gardner was placed over the brigade (19th, 22nd, 25th, 26-50th, and 39th AL regiments) and led it into Kentucky. It was present at Mumfordsville, and it skirmished at Perryville. It came back with the army and fought at Murfreesboro (94 casualties). Gen'l Zachariah Deas then assumed command of the brigade. The regiment was in the line of battle which moved to assault US Gen'l William Rosecrans at Chickamauga, where it lost 5 color bearers and 175 killed and wounded out of about 400 engaged. They lost lightly at Missionary Ridge and wintered at Dalton, GA, claiming 272 men and 171 arms. The regiment, under the command of Gen'l George D. Johnston of Perry County, participated in the campaign from Dalton to Atlanta, losing gradually by the constant fighting. At Atlanta, 22 and 28 July, the loss of the regiment was high, as it was at Jonesboro. It moved into Tennessee with Gen'l John Bell Hood and suffered severely at Franklin, lightly at Nashville. The regiment was transferred beyond the Edisto and moved into North Carolina, skirmishing with the advance of US Gen'l George Thomas' army. The loss at Kinston and Bentonville was light, Col. Harry Toulmin leading the brigade. The regiment was consolidated with the 25th Infantry in the field in early 1863; it was also consolidated with the 25th, 39th, and 26-50th at Smithfield, 9 April 1865, with H. T. Toulmin as Colonel, N. B. Rouse (Butler) as Lt. Col., and Robert Donald (Limestone) as Major, and then surrendered at Greenesboro, NC, on 26 April 1865.
Cols. Zachariah Cantey Deas (wounded, Shiloh, promoted to Brig. Gen'l), John Calhoun Marrast (died in service, 1863), Benjamin R. Hart (KIA, Atlanta, Jan., 1864), and Harry Theophilus Toulmin; Lt. Cols. John Calhoun Marrast (promoted), John Weedon (KIA, Chickamauga), Benjamin R. Hart (promoted), Harry Theophilus Toulmin (promoted), and E. Herbert Armistead (KIA, Franklin); Majors Robert Burbage Armistead (KIA, Shiloh), John Weeden (promoted), Benjamin R. Hart (wounded, Chickamauga, promoted), Thomas McCarroll Prince (wounded, Franklin); and Adjutants Elias F. Travis (wounded, Shiloh, and transferred), William G. Smith (resigned), J. L. Lockwood (wounded, Jonesboro).
Co. "A" (Walker): John Weedon (promoted to Major); Isaac M. Whitney
Co. "B", Frank Lyon Rifles (Clarke): James Deas Nott (KIA, Chickamauga); Joseph R. Cowan (wounded, near Marietta)
Co. "C", Brownrigg Warriors (Choctaw): Abner C. Gaines (KIA, Shiloh); Thomas McCarroll Prince (wounded, Chickamauga; promoted to Major); Joseph R. Cowan (wounded near Mobile)
Co. "D" (Cherokee): Stephen R. Hood (resigned, 10 Jan 62); Edward Herbert Armistead (promoted); T. C. Hagood; Thomas M. Brindley (KIA, near Atlanta, July 64)
Co. "E" (Calhoun): John R. Northcutt (resigned, 13 June 62); Jacob G. Mordecai
Co. "F" (Randolph): O. W. Shepherd (wounded, near Shiloh; resigned, 27 May 62); James B. Martin; Hures Austill
Co. "G" (Randolph): R. G. Roberts (dismissed, 25 June 63); S. H. Pairs (deserted, 27 Oct 62); Benjamin B. Little (KIA, Jonesboro); William O. Baldwin (KIA, Franklin)
Co. "H", Sam Cooper Rifles (Mobile): Wilton L. Young (promoted to Major, 10th Bn.); Harry T. Toulmin (wounded, Shiloh; promoted to Major); Simon Franklin Preston
Co. "I" (Pike): Andrew P. Love (wounded, Shiloh; resigned, 1 July 62; transferred to Jeff Davis' Cavalry); Willis C. Wood (wounded, Murfreesboro; resigned, 31 Oct 64); Willis H. Henderson (wounded, Kinston)
Co. "K" (Montgomery and Pike): Benjamin R. Hart (promoted to Major); Hugh W. Henry.