The Arkansas 16th Infantry Regiment completed its organization at Rogers, Benton County, Arkansas, in November, 1861, then moved to Elm Springs and remained there until February, 1862. Its members were recruited in the counties of Johnson, Carroll, Stone, Washington, Pike, Madison, and Searcy. The 16th was involved in the fight at Elkhorn Tavern and after the battle had 24 officers and 282 men present for duty. Ordered east of the Mississippi River, it took an active part in the conflicts at Iuka and Corinth where it reported 13 killed and 29 wounded. Later the unit was assigned to Beall's Brigade, Department of Mississippi and East Louisiana, and was captured when Port Hudson fell. It was not reorganized after the exchange.
Colonels J. F. Hill and David Provence, Lieutenant Colonels William T. Neal and Benjamin T. Pixlee, and Majors Samuel Farmer and J. M. Pittman.