This battalion was formed by the addition of five companies which had been organized in September and October, 1862 to four companies which had previously served in the 4th (John P. Murray's) Tennessee Cavalry Regiment, which was disbanded in January, 1863. T. B. Murray was formerly lieutenant colonel of the 16th Tennessee Infantry Regiment, and was frequently referred to as lieutenant colonel of the 22nd Infantry Battalion. However, his official rank seems to have been major of the 22nd Infantry Battalion.

The 22nd joined the Army of Tennessee after the Battle of Murfreesboro and was placed in General M.J. Wright's Brigade. However, that summer the unit merged into the 38th Tennessee Infantry Regiment. Lindsley does not have a separate history for this unit, but there is a separate memorial roll, most of the deaths showing after the merge into the 39th.

Thomas E. Taylor, Co. "A". Organized October 1, 1862 at McMinnville. Men from White County.
James S. Gribble, Co. "B". Organized October 1, 1862 at McMinnville. Men from White County.
James M. Freiley, Co. "C". Organized September 10, 1862 at Pikeville, Bledsoe County.
John W. Bass, Co. "D". Organized November 26, 1862 at McMinnville, Warren County.